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Fabgennix
EHD3 Polyclonal Antibody, FITC
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Product Details
EHD3-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 525-555 on human EH-domain containing protein 3.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The EHD3 gene encodes the EH-domain containing protein 3, part of the EHD protein family involved in the regulation of endocytic recycling and membrane trafficking. EHD3 plays a crucial role in the endosomal transport system, impacting how receptors and other membrane proteins are recycled back to the cell surface after internalization. This protein aids in maintaining cellular homeostasis by ensuring the efficient sorting and transport of cargo through the endosomal system. EHD3 has been implicated in various cellular functions, including insulin signaling, receptor recycling, and neuronal development, and significantly influences synaptic transmission and plasticity. Alterations in EHD3 expression or function can disrupt endosomal trafficking processes and are linked to conditions such as neurodegenerative diseases and cancer. Research on EHD3 is focused on uncovering its role in membrane dynamics and identifying potential therapeutic strategies for disorders involving dysfunctional endocytic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EH domain-containing protein 3; EH-domain containing protein 2; PAST homolog 3; similar to EHD1; unnamed protein product
Gene Aliases: EHD2; EHD3; PAST3
UniProt ID: (Human) Q9NZN3, (Rat) Q8R491, (Mouse) Q9QXY6
Entrez Gene ID: (Human) 30845, (Rat) 192249, (Mouse) 57440
receptor recycling
endocytosis
protein transport
cell projection organization
endocytic recycling
early endosome to Golgi transport
protein homooligomerization
regulation of cardiac muscle contraction
cilium morphogenesis
protein localization to plasma membrane
regulation of cardiac muscle cell membrane potential
Golgi to lysosome transport
regulation of Golgi organization
regulation of cardiac conduction
protein targeting to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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