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Invitrogen
EHD3 Polyclonal Antibody
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FIGURE: 1 / 4
EHD3 Antibody (PA5-25963) in IHC (P)
Immunohistochemistry analysis of EHD3 in formalin fixed and paraffin embedded brain tissue. Samples were incubated with EHD3 polyclonal antibody (Product # PA5-25963) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-25963
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 22-48 amino acids from the N-terminal region of human EHD3
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, mouse and rat based on sequence homology.
Target Information
The EHD3 gene encodes the EH-domain containing protein 3, part of the EHD protein family involved in the regulation of endocytic recycling and membrane trafficking. EHD3 plays a crucial role in the endosomal transport system, impacting how receptors and other membrane proteins are recycled back to the cell surface after internalization. This protein aids in maintaining cellular homeostasis by ensuring the efficient sorting and transport of cargo through the endosomal system. EHD3 has been implicated in various cellular functions, including insulin signaling, receptor recycling, and neuronal development, and significantly influences synaptic transmission and plasticity. Alterations in EHD3 expression or function can disrupt endosomal trafficking processes and are linked to conditions such as neurodegenerative diseases and cancer. Research on EHD3 is focused on uncovering its role in membrane dynamics and identifying potential therapeutic strategies for disorders involving dysfunctional endocytic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EH domain-containing protein 3; EH-domain containing protein 2; PAST homolog 3; similar to EHD1; unnamed protein product
Gene Aliases: EHD2; EHD3; PAST3
UniProt ID: (Human) Q9NZN3, (Mouse) Q9QXY6
Entrez Gene ID: (Human) 30845, (Mouse) 57440
receptor recycling
endocytosis
protein transport
cell projection organization
endocytic recycling
early endosome to Golgi transport
protein homooligomerization
regulation of cardiac muscle contraction
cilium morphogenesis
protein localization to plasma membrane
regulation of cardiac muscle cell membrane potential
Golgi to lysosome transport
regulation of Golgi organization
regulation of cardiac conduction
protein targeting to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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