EHMT1, also known as EUHMTASE1, is a histone methyltransferase. This protein methylates 'Lys-9' of histone H3 in vitro. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1 is Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in the G0/G1 transition of the cell cycle.
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Protein Aliases: EHMT1; Eu-HMTase1; Euchromatic histone-lysine N-methyltransferase 1; EUHMTASE1; G9a-like protein 1; GLP; GLP1; H3-K9-HMTase 5; Histone H3-K9 methyltransferase 5; Histone-lysine N-methyltransferase EHMT1; histone-lysine N-methyltransferase, H3 lysine-9 specific 5; KIAA1876; KMT1D; Lysine N-methyltransferase 1D
Gene Aliases: bA188C12.1; EHMT1; Eu-HMTase1; EUHMTASE1; FP13812; GLP; GLP1; KIAA1876; KMT1D
UniProt ID: (Human) Q9H9B1
Entrez Gene ID: (Human) 79813