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Invitrogen
EHMT1 Polyclonal Antibody
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FIGURE: 1 / 1
EHMT1 Antibody (PA5-11209) in WB
Western blot analysis of EHMT1 in 293 cell lysates. Samples were incubated with EHMT1 polyclonal antibody (Product # PA5-11209). Lysates: 2 µg/lane. 293 cell lysates either nontransfected (Lane 1) or transiently transfected with the EUHMTASE gene (Lane 2).
Product Details
PA5-11209
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 979-1010 amino acids from the central region of human EHMT1 (EUHMTASE1)
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
EHMT1, also known as EUHMTASE1, is a histone methyltransferase. This protein methylates 'Lys-9' of histone H3 in vitro. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1 is Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in the G0/G1 transition of the cell cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EHMT1 intronic transcript 1; Eu-HMTase1; Euchromatic histone-lysine N-methyltransferase 1; G9a-like protein 1; GLP; H3-K9-HMTase 5; Histone H3-K9 methyltransferase 5; Histone-lysine N-methyltransferase EHMT1; histone-lysine N-methyltransferase, H3 lysine-9 specific 5; Lysine N-methyltransferase 1D; unnamed protein product
Gene Aliases: EHMT1; EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812; GLP; GLP1; KIAA1876; KLEFS1; KMT1D
UniProt ID: (Human) Q9H9B1
Entrez Gene ID: (Human) 79813
transcription corepressor binding
p53 binding
protein binding
methyltransferase activity
zinc ion binding
protein-lysine N-methyltransferase activity
transferase activity
histone methyltransferase activity
metal ion binding
histone methyltransferase activity (H3-K9 specific)
histone methyltransferase activity (H3-K27 specific)
C2H2 zinc finger domain binding
histone H3 methyltransferase activity
histone H3K9me2 methyltransferase activity
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
methylation-dependent chromatin silencing
peptidyl-lysine monomethylation
peptidyl-lysine dimethylation
methylation
regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
regulation of embryonic development
response to fungicide
positive regulation of cold-induced thermogenesis
facultative heterochromatin formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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