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Bioss
EID1 Polyclonal Antibody
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Product Details
BS-6138R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human EID1, amino acids 111-187.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 21 kDa pRb-associated protein; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1; E1A-like inhibitor of differentiation 1; EID; EID-1; EID1; EP300-interacting inhibitor of differentiation 1; NB4 apoptosis related protein; Rb- and p300-binding protein EID-1; retinoblastoma protein-associated protein
Gene Aliases: 2610002K20Rik; C15orf3; CRI1; EID-1; EID1; IRO45620; ORF12; PNAS-22; PTD014; RBP21; RGD1562702
UniProt ID: (Human) Q9Y6B2, (Mouse) Q9DCR4
Entrez Gene ID: (Human) 23741, (Rat) 499882, (Mouse) 58521
negative regulation of transcription from RNA polymerase II promoter
cell differentiation
regulation of histone acetylation
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
transcription, DNA-templated
cell cycle
regulation of cell differentiation
regulation of transcription, DNA-templated
regulation of catalytic activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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