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Proteintech
EIF2S1/EIF2A Polyclonal Antibody, CoraLite® Plus 647
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FIGURE: 1 / 1
EIF2S1/EIF2A Antibody (CL647-11170) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.2 µg CoraLite® Plus 647 Anti-Human EIF2S1/EIF2A (CL647-11170) (red), or 0.2 µg CL647-30000 Rabbit IgG (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL647-11170
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
654/674 nm
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT TLERTEGLSV LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV DGDDDAEEME AKAED
Target Information
EIF2a (Eukaryotic translation initiation factor 2A) is a heterotrimer composed of three subunits (alpha, beta, and gamma). This translation initiation factor drives binding of initiator methionyl-tRNA to the 40S ribosome in an AUG-dependent manner to form the 43S pre-initiation complex. The polypeptide can be phosphorylated by related protein kinases activated in response to stress. Phosphorylated EIF2A inhibits EIF2B activity and prevents guanine nucleotide exchange.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: eIF-2-alpha; EIF-2A; EIF-2alpha; eIF2 alpha; eIF2-alpha; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; eukaryotic translation initiation factor 2A; translational initiation factor eIF-2, alpha subunit; unnamed protein product
Gene Aliases: 0910001O23Rik; 2410026C18Rik; 35kDa; EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A; eIF2alpha; EIF2S1
UniProt ID: (Human) P05198, (Rat) P68101, (Mouse) Q6ZWX6
Entrez Gene ID: (Human) 1965, (Rat) 54318, (Mouse) 13665
mitophagy
translation
translational initiation
regulation of translation
negative regulation of translational initiation in response to stress
stress granule assembly
cellular response to amino acid starvation
cellular response to oxidative stress
cellular response to heat
cellular response to UV
response to endoplasmic reticulum stress
regulation of translation in response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
regulation of translational initiation in response to stress
mitochondrial respiratory chain supercomplex assembly
HRI-mediated signaling
response to kainic acid
response to manganese-induced endoplasmic reticulum stress
positive regulation of type B pancreatic cell apoptotic process
protein autophosphorylation
positive regulation of defense response to virus by host
mitophagy in response to mitochondrial depolarization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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