Immunogen sequence: SGAAEYLYF FRVLVPATDR NALSSLWGKL ASEILMQNWD AAMEDLTRLK ETIDNNSVSS PLQSLQQRTW LIHWSLFVFF NHPKGRDNII DLFLYQPQYL NAIQTMCPHI LRYLTTAVIT NKDVRKRRQV LKDLVKVIQQ ESYTYKDPIT EFVECLYVNF DFDGAQKKLR ECESVLVNDF FLVACLEDFI ENARLFIFET FCRIHQCISI NMLADKLNMT PEEAERWIVN LIRNARLDAK IDSKLGHVVM GNNAVSPYQQ VIEKTKSLSF RSQMLAMNIE KKLNQNSRSE APNWATQDSG FY (145-445 aa encoded by BC008419)
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: eIF-3 p48; EIF3E; Eukaryotic translation initiation factor 3 subunit 6; Eukaryotic translation initiation factor 3 subunit E; eukaryotic translation initiation factor 3 subunit E isoform 2 transcript; eukaryotic translation initiation factor 3, subunit 6 (48kD); eukaryotic translation initiation factor 3, subunit 6 48kDa; eukaryotic translation initiation factor 3, subunit E; mammary tumor integration site 6; Mammary tumor-associated protein INT-6; mammary tumor-associated protein INT6; MMTV integration site 6; murine mammary tumor integration site 6 (oncogene homolog); Viral integration site protein INT-6; Viral integration site protein INT-6 homolog
Gene Aliases: 48kDa; eIF3-p46; EIF3-P48; EIF3E; EIF3S6; INT6
Molecular Function: translation initiation factor