Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
12227-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EIF4E2 Fusion Protein Ag2864 (1-245 aa encoded by BC021690)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNNKFDALK DDDSGDHDQN EENSTQKDGE KEKTERDKNQ SSSKRKAVVP GPAEHPLQYN YTFWYSRRTP GRPTSSQSYE QNIKQIGTFA SVEQFWRFYS HMVRPGDLTG HSDFHLFKEG IKPMWEDDAN KNGGKWIIRL RKGLASRCWE NLILAMLGEQ FMVGEEICGA VVSVRFQEDI ISIWNKTASD QATTARIRDT LRRVLNLPPN TIMEYKTHTD SIKMPGRLGP QRLLFQNLWK PRLNVP (1-245 aa encoded by B C021690)
Target Information
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: eIF-4E type 2; eIF4E type 2; eIF4E-2; eIF4E-like cap-binding protein; eIF4E-like protein 4E-LP; eukar; Eukaryotic translation initiation factor 4E homologous protein; eukaryotic translation initiation factor 4E like 3; eukaryotic translation initiation factor 4E member 2; Eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; h4EHP; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 2; mRNA cap-binding protein type 3
Gene Aliases: 2700069E09Rik; 4E-LP; 4EHP; AI036339; AV129531; D0H0S6743E; EIF4E2; EIF4EL3; IF4e
UniProt ID: (Human) O60573, (Mouse) Q8BMB3
Entrez Gene ID: (Human) 9470, (Rat) 363275, (Mouse) 26987
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support