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Invitrogen
ELAC2 Polyclonal Antibody
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FIGURE: 1 / 3
ELAC2 Antibody (PA5-78553) in IHC (P)
ELAC2 Polyclonal Antibody detects ELAC2 protein at cytoplasm and nucleus in human breast carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. ELAC2 Polyclonal Antibody (Product # PA5-78553) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-78553
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ELAC2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.73 mg/mL
Amount
73 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Jurkat, Raji, NCI-H929
Predicted Reactivity: Chimpanzee (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ELAC2 encodes a protein that has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: elaC homolog 2; elaC homolog 2 (E. coli) isoform ELAC2_1; elaC homolog 2 (E. coli) isoform ELAC2_2; ElaC homolog protein 2; elaC-like protein 2; ELAC2; Heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z 2; unnamed protein product; Zinc phosphodiesterase ELAC protein 2
Gene Aliases: COXPD17; ELAC2; ELC2; HPC2
UniProt ID: (Human) Q9BQ52
Entrez Gene ID: (Human) 60528
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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