This target displays homology in the following species: Cow: 86%; Dog: 86%; Guinea Pig: 85%; Horse: 92%; Human: 92%; Mouse: 100%; Pig: 100%; Rabbit: 92%; Rat: 100%
ELF5 is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus.
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Protein Aliases: E74-like factor 5; E74-like factor 5 (ets domain transcription factor); E74-like factor 5 ESE-2a; E74-like factor 5 ESE-2b-like; ELF5; Epithelium specific Ets-2; Epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2; ESE-2; ESE2; ETS-related transcription factor Elf-5
Gene Aliases: BOS_15099; ELF5; ESE-2; ESE-5; ESE-5.; ESE2