Immunogen sequence: HPRPAVVLPS AAPAGAAAPP SGSRSTSPSP LEACLEAEEA GLPLQVILTP PEAPNLKSEE LNVEPGLGRA LPPEVKVEGP KEE
The transcription factor Elk1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by Elk1. Elk1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo.
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Protein Aliases: ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS-like gene 1; tyrosine kinase (ELK1) oncogene
Gene Aliases: ELK1
UniProt ID: (Human) P19419
Entrez Gene ID: (Human) 2002