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Proteintech
ELL2 Polyclonal Antibody
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Product Details
12727-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ELL2 Fusion Protein Ag3428 (341-640 aa encoded by BC028412)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TNRVPPTLN GHLNPTSEKS AAGLPLPPAA AAIPTPPPLP STYLPISHPP QIVNSNSNSP STPEGRGTQD LPVDSFSQND SIYEDQQDKY TSRTSLETLP PGSVLLKCPK PMEENHSMSH KKSKKKSKKH KEKDQIKKHD IETIEEKEED LKREEEIAKL NNSSPNSSGG VKEDCTASME PSAIELPDYL IKYIAIVSYE QRQNYKDDFN AEYDEYRALH ARMETVARRF IKLDAQRKRL SPGSKEYQNV HEEVLQEYQK IKQSSPNYHE EKYRCEYLHN KLAHIKRLIG EFDQQQAESW S (341-640 aa encoded by BC028412)
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: eleven-nineteen lysine-rich leukemia gene 2; ELL-related RNA polymerase II, elongation factor; elongation factor RNA for polymerase II 2; elongation factor, RNA polymerase II, 2; RNA polymerase II elongation factor ELL2
Gene Aliases: ELL2
UniProt ID: (Human) O00472, (Mouse) Q3UKU1
Entrez Gene ID: (Human) 22936, (Mouse) 192657, (Rat) 309918
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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