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Product Details
PA5-103129
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
Immunocytochemistry (ICC/IF) |
1:100-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Non-human primate, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human Elmo1, corresponding to a region within C-terminal amino acids. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2852499 |
Target Information
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. Similarity to a C. elegans protein suggests that this protein may function in apoptosis and in cell migration. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ced-12 homolog 1; engulfment and cell motility 1 splice 1; engulfment and cell motility 1, ced-12 homolog; Engulfment and cell motility protein 1; MGC126406; OTTHUMP00000207056; OTTHUMP00000207060; Protein ced-12 homolog
Gene Aliases: 6330578D22Rik; C230095H21Rik; CED-12; CED12; ELMO-1; ELMO1; ELMO1s; KIAA0281
UniProt ID: (Human) Q92556, (Mouse) Q8BPU7
Entrez Gene ID: (Human) 9844, (Mouse) 140580, (Rat) 361251
Molecular Function:
scaffold/adaptor protein
phagocytosis, engulfment
apoptotic process
movement of cell or subcellular component
cell migration
Rac protein signal transduction
actin cytoskeleton organization
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of GTPase activity
vascular endothelial growth factor receptor signaling pathway
regulation of defense response to virus by virus
phagocytosis
actin filament-based process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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