Sequence of this protein is as follows: AQVLRNNPDA LSDVGEVPYW VLEPVLEGWR PDQLYRRKKD NHALVRETDE LRRNHCFQDF KEEKPQENKT WREQYLRLPD APEQRLRVMT TNIRSARGNN PNGREAKMIC FKSVAKTPYD TSRRQEKSAG DADPENGEIK PASKPAGSSH TPSSQSSSGG GRDSSSSILR WLPEKRANPC LSSSNEHAAP AAKTRKQAAK KVAPLMAKAI RDYKRRFSRR
This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis.
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Protein Aliases: EloA2; Elongin-A2; RNA polymerase II transcription factor SIII subunit A2; transcription elongation factor (SIII) elongin A2 elongin A2; Transcription elongation factor B polypeptide 3B
Gene Aliases: ELOA2; HsT832; TCEB3B; TCEB3L
UniProt ID: (Human) Q8IYF1
Entrez Gene ID: (Human) 51224