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Proteintech
ELOVL6 Polyclonal Antibody
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Product Details
21160-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ELOVL6 Fusion Protein Ag14163 (1-80 aa encoded by BC001305)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNMSVLTLQ EYEFEKQFNE NEAIQWMQEN WKKSFLFSAL YAAFIFGGRH LMNKRAKFEL RKPLVLWSLT LAVFSIFGAL R (1-80 aa encoded by BC001305)
Target Information
Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of fatty acyl-CoA elongase gene family that converts palmitic to stearic acid and it has been shown to be a target of SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase ELOVL6 was predicted to be important for tissue fatty acid composition. Recent studies suggest that inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3-keto acyl-CoA synthase ELOVL6; Elongation of very long chain fatty acids protein 6; ELOVL FA elongase 6; ELOVL family member 6, elongation of long chain fatty acids; ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast); ELOVL fatty acid elongase 6; Fatty acid elongase 2; Fatty acyl-CoA elongase; hELO2; Long chain fatty acid elongase; long chain fatty acyl elongase; Long-chain fatty-acyl elongase; Myelin-associated SUR4 protein; rELO2; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoA synthase 6; Very long chain fatty acid elongase 6; very-long-chain 3-oxoacyl-CoA synthase 6
Gene Aliases: C77826; ELOVL6; FACE; FAE; LCE; Lce2; Masr; rELO2
UniProt ID: (Human) Q9H5J4, (Mouse) Q920L5, (Rat) Q920L6
Entrez Gene ID: (Human) 79071, (Mouse) 170439, (Rat) 171402
unsaturated fatty acid biosynthetic process
fatty acid elongation, saturated fatty acid
sphingolipid biosynthetic process
fatty acid elongation, monounsaturated fatty acid
fatty acid elongation, polyunsaturated fatty acid
long-chain fatty-acyl-CoA biosynthetic process
long-chain fatty acid biosynthetic process
very long-chain fatty acid biosynthetic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
fatty acid elongation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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