Recommended positive controls: MCF-7.
Predicted reactivity: Mouse (84%), Rat (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
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Protein Aliases: AUTS1; engrailed homolog 2; engrailed-2; Homeobox protein en-2; Homeobox protein engrailed-2; hu-En-2
Gene Aliases: EN2
UniProt ID: (Human) P19622
Entrez Gene ID: (Human) 2020
Molecular Function: homeodomain transcription factor