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Invitrogen
ENDOG Polyclonal Antibody
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FIGURE: 1 / 4
ENDOG Antibody (PA5-17329) in WB
Western blot was performed using Anti-ENDOG Polyclonal Antibody (Product # PA5-17329) and a 32 kDa band corresponding to ENDOG was observed across cell lines and tissue extracts tested along with an uncharacterized band at ~80 kDa in tissues. Membrane enriched extracts (30 µg lysate) of Hep G2 (Lane 1), A549 (Lane 2), HeLa (Lane 3), PC-3 (Lane 4), tissue extracts of Mouse Liver (Lane 5), Mouse Kidney (Lane 6) and Rat Liver (Lane 7) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were t... View More
Product Details
PA5-17329
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Cys122 of human Endonuclease G
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endo G; Endonuclease G, mitochondrial; mitochondrial endonuclease G
Gene Aliases: ENDOG
UniProt ID: (Human) Q14249, (Mouse) O08600
Entrez Gene ID: (Human) 2021, (Mouse) 13804, (Rat) 362100
single-stranded DNA endodeoxyribonuclease activity
magnesium ion binding
nucleic acid binding
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
endoribonuclease activity
deoxyribonuclease activity
protein binding
hydrolase activity
protein homodimerization activity
metal ion binding
in utero embryonic development
DNA metabolic process
DNA catabolic process
apoptotic DNA fragmentation
response to tumor necrosis factor
positive regulation of apoptotic process
response to antibiotic
nucleic acid phosphodiester bond hydrolysis
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of apoptotic DNA fragmentation
DNA recombination
cellular response to DNA damage stimulus
response to mechanical stimulus
positive regulation of autophagy
negative regulation of TOR signaling
mitochondrial DNA catabolic process
response to estradiol
cellular response to oxidative stress
cellular response to calcium ion
cellular response to glucose stimulus
cellular response to hypoxia
positive regulation of mitochondrial DNA replication
aging
neuron death in response to oxidative stress
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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