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Invitrogen
ENDOG Polyclonal Antibody
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Product Details
PA5-30018
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human EndoG. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.72 mg/mL
Amount
72 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: A549, HepG2, mouse brain.
Predicted reactivity: Mouse (95%), Rat (95%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endo G; Endonuclease G, mitochondrial; mitochondrial endonuclease G
Gene Aliases: ENDOG
UniProt ID: (Human) Q14249, (Mouse) O08600
Entrez Gene ID: (Human) 2021, (Mouse) 13804
single-stranded DNA endodeoxyribonuclease activity
magnesium ion binding
nucleic acid binding
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
endoribonuclease activity
deoxyribonuclease activity
protein binding
hydrolase activity
protein homodimerization activity
metal ion binding
in utero embryonic development
DNA metabolic process
DNA catabolic process
apoptotic DNA fragmentation
response to tumor necrosis factor
positive regulation of apoptotic process
response to antibiotic
nucleic acid phosphodiester bond hydrolysis
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of apoptotic DNA fragmentation
DNA recombination
cellular response to DNA damage stimulus
response to mechanical stimulus
positive regulation of autophagy
negative regulation of TOR signaling
mitochondrial DNA catabolic process
response to estradiol
cellular response to oxidative stress
cellular response to calcium ion
cellular response to glucose stimulus
cellular response to hypoxia
positive regulation of mitochondrial DNA replication
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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