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ENPP1 Polyclonal Antibody

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ENPP1 Polyclonal Antibody

Product Details

BS-4913R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human ENPP1, amino acids 41-140.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alkaline phosphodiesterase 1; Alkaline phosphodiesterase I; E-NPP 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; HGNC:3356; Ly-41; Ly-41 antigen; Lymphocyte antigen 41; Membrane component chromosome 6 surface marker 1; membrane component, chromosome 6, surface marker 1; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTHUMP00000043194; Phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein 1; Plasma-cell membrane glycoprotein PC-1; unnamed protein product

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Gene Aliases: 4833416E15Rik; AI428932; ARHR2; C76301; CD203c; COLED; E-NPP 1; E-NPP1; ENPP1; Ly-41; M6S1; NPP1; NPPS; PC-1; PC1; Pca; Pca-1; PCA1; PDNP1; ttw; twy

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UniProt ID: (Human) P22413, (Mouse) P06802, (Rat) Q924C3

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Entrez Gene ID: (Human) 5167, (Mouse) 18605, (Rat) 85496

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Function(s)
nucleic acid binding 3',5'-cyclic-AMP phosphodiesterase activity exonuclease activity phosphodiesterase I activity nucleotide diphosphatase activity scavenger receptor activity insulin receptor binding calcium ion binding protein binding ATP binding zinc ion binding hydrolase activity phosphatase activity polysaccharide binding GTP diphosphatase activity UTP diphosphatase activity protein homodimerization activity metal ion binding nucleoside-triphosphate diphosphatase activity ATP diphosphatase activity 3'-phosphoadenosine 5'-phosphosulfate binding cyclic-GMP-AMP hydrolase activity molecular_function NADH pyrophosphatase activity
Process(es)
generation of precursor metabolites and energy phosphate-containing compound metabolic process receptor-mediated endocytosis immune response biological_process nucleoside triphosphate catabolic process negative regulation of ossification negative regulation of cell growth inorganic diphosphate transport cellular phosphate ion homeostasis sequestering of triglyceride biomineral tissue development negative regulation of protein autophosphorylation cellular response to insulin stimulus negative regulation of fat cell differentiation negative regulation of glycogen biosynthetic process negative regulation of glucose import negative regulation of insulin receptor signaling pathway bone remodeling 3'-phosphoadenosine 5'-phosphosulfate metabolic process nucleic acid phosphodiester bond hydrolysis gene expression vesicle-mediated transport bone mineralization melanocyte differentiation regulation of bone mineralization negative regulation of bone mineralization response to ATP ATP metabolic process animal organ development phosphate ion homeostasis nucleic acid metabolic process negative regulation of hh target transcription factor activity
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