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Fabgennix
ENPP2 Polyclonal Antibody
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Product Details
ATX-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 778-818 on human Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Autotaxin; autotaxin-t; AutotaxinATX; E-NPP 2; ectonucleotide pyrophosphatase/phosphodiesterase 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Extracellular lysophospholipase D; FLJ26803; LysoPLD; phosphodiesterase I/nucleotide pyrophosphatase 2; phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin); plasma lysophospholipase D; unnamed protein product
Gene Aliases: ATX; ATX-X; AUTOTAXIN; ENPP2; LysoPLD; NPP2; Npps2; PD-IALPHA; PDNP2
UniProt ID: (Human) Q13822, (Mouse) Q9R1E6, (Rat) Q64610
Entrez Gene ID: (Human) 5168, (Mouse) 18606, (Rat) 84050
nucleic acid binding
phosphodiesterase I activity
lysophospholipase activity
phospholipase D activity
scavenger receptor activity
calcium ion binding
zinc ion binding
hydrolase activity
polysaccharide binding
metal ion binding
alkylglycerophosphoethanolamine phosphodiesterase activity
catalytic activity
nucleotide diphosphatase activity
negative regulation of cell-matrix adhesion
lipid metabolic process
chemotaxis
immune response
metabolic process
positive regulation of cell proliferation
phospholipid catabolic process
positive regulation of epithelial cell migration
lipid catabolic process
regulation of cell migration
phosphatidylcholine catabolic process
regulation of angiogenesis
positive regulation of oligodendrocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of focal adhesion assembly
cell chemotaxis
nucleic acid phosphodiester bond hydrolysis
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of lamellipodium morphogenesis
phospholipid metabolic process
vesicle-mediated transport
sphingolipid catabolic process
cell motility
receptor-mediated endocytosis
estrous cycle
cellular response to cadmium ion
cellular response to estradiol stimulus
response to polycyclic arene
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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