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Product Details
12643-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:4,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
ENPP6 Fusion Protein Ag3339 (90-440 aa encoded by BC035035) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.25 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: IGNYMWDPT TNKSFDIGVN KDSLMPLWWN GSEPLWVTLT KAKRKVYMYY WPGCEVEILG VRPTYCLEYK NVPTDINFAN AVSDALDSFK SGRADLAAIY HERIDVEGHH YGPASPQRKD ALKAVDTVLK YMTKWIQERG LQDRLNVIIF SDHGMTDIFW MDKVIELNKY ISLNDLQQVK DRGPVVSLWP APGKHSEIYN KLSTVEHMTV YEKEAIPSRF YYKKGKFVSP LTLVADEGWF ITENREMLPF WMNSTGRREG WQRGWHGYDN ELMDMRGIFL AFGPDFKSNF RAAPIRSVDV YNVMCNVVGI TPLPNNGSWS RVMCMLKGRA STAPPVWPSH CALALILLFL LA (90-440 aa encoded by BC035035)
Target Information
Choline-specific glycerophosphodiester phosphodiesterase. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B830047L21Rik; Choline-specific glycerophosphodiester phosphodiesterase; E-NPP 6; E-NPP6; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; glycerophosphocholine cholinephosphodiesterase; Glycerophosphocholine cholinephosphodiesterase ENPP6; GPC-Cpde; NPP-6
Gene Aliases: 4833421B01Rik; B830047L21Rik; D8Ertd514e; E-NPP 6; ENPP6; NPP6; UNQ1889/PRO4334
UniProt ID: (Human) Q6UWR7, (Mouse) Q8BGN3, (Rat) B0BND0
Entrez Gene ID: (Human) 133121, (Mouse) 320981, (Rat) 306460
phosphoric diester hydrolase activity
glycerophosphodiester phosphodiesterase activity
glycerophosphocholine cholinephosphodiesterase activity
catalytic activity
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
photoreceptor cyclic-nucleotide phosphodiesterase activity
hydrolase activity
7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
inositol phosphosphingolipid phospholipase activity
inositol phosphorylceramide phospholipase activity
mannosyl-inositol phosphorylceramide phospholipase activity
mannosyl-diinositol phosphorylceramide phospholipase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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