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Invitrogen
EPC1 Polyclonal Antibody
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Product Details
PA5-76826
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human EPC1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
EPC1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781P2312; Enhancer of polycomb homolog 1; Epl 1; polycomb-group protein; EPC; unnamed protein product
Gene Aliases: 2400007E14Rik; 5730566F07Rik; A930032N02Rik; EPC1; Epl1; mir-1893
UniProt ID: (Human) Q9H2F5, (Mouse) Q8C9X6
Entrez Gene ID: (Human) 80314, (Mouse) 13831
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
double-strand break repair via nonhomologous end joining
chromatin organization
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
spermatid development
cell differentiation
sperm chromatin condensation
regulation of apoptotic process
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
positive regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
regulation of transcription, DNA-templated
chromatin modification
regulation of growth
histone H4 acetylation
histone H2A acetylation
positive regulation of striated muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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