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Invitrogen
EPCR Monoclonal Antibody (RCR-252)
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Product Details
MA5-33375
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
RCR-252
Immunogen
Human EPCR-positive RE-1 cells
Conjugate
Form
Liquid
Concentration
100 µg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Product is supplied at 1 mL (100 µL/mL).
Application Notes: Flow cytometry- This antibody stains the extracellular domain of human EPCR. RE-1 cells were used as a positive control and N1 cells were used as a negative control. Western blot - A non-reduced sample treatment was used. The observed band size is 50 kDa. Functional Assay: This antiboyd functions as blocking antbody. It ablates APC binding to EPCR and blocks APC-mediated signaling. The antibody was functionally tested by pretreatment of cells with 10-25 µg/mL RCR-252. Positive control: RE-1 (rat 3Y1 fibroblasts stably transfected with human EPCR); Negative control: N1 cells.
Target Information
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Activated protein C receptor; APC receptor; bA42O4.2; CD201; CD201 antigen; cell cycle, centrosome-associated protein; centrocyclin; Endothelial cell protein C receptor; Endothelial protein C receptor; PROCR; protein C receptor, endothelial; unnamed protein product
Gene Aliases: CCCA; CCD41; EPCR; PROCR
UniProt ID: (Human) Q9UNN8
Entrez Gene ID: (Human) 10544
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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