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Invitrogen
EPM2A Polyclonal Antibody
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FIGURE: 1 / 4
EPM2A Antibody (PA5-28073) in ICC/IF
EPM2A Polyclonal Antibody detects EPM2A protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in ice-cold MeOH for 5 min. Green: EPM2A protein stained by EPM2A Polyclonal Antibody (Product # PA5-28073) diluted at 1:500. Blue: Hoechst 33343 staining.
Product Details
PA5-28073
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Laforin. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 40% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual-specificity phosphatase; epilepsy, progressive myoclonus type 2, Lafora disease (laforin); epilepsy, progressive myoclonus type 2A, Lafora disease (laforin); EPM2A, laforin glucan phosphatase; Glucan phosphatase; Glycogen phosphatase; Lafora PTPase; Laforin; LAFPTPase; RP1-28C20.2; unnamed protein product
Gene Aliases: EPM2; EPM2A; MELF; MELF2
UniProt ID: (Human) O95278
Entrez Gene ID: (Human) 7957
glycogen (starch) synthase activity
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
hydrolase activity
phosphatase activity
carbohydrate phosphatase activity
carbohydrate binding
polysaccharide binding
identical protein binding
protein homodimerization activity
protein dimerization activity
glycogen binding
starch binding
autophagosome assembly
regulation of cell growth
glycogen metabolic process
glycogen biosynthetic process
protein dephosphorylation
phosphate-containing compound metabolic process
calcium ion transport
autophagy
mitochondrion organization
nervous system development
negative regulation of metabolic process
regulation of gene expression
negative regulation of gene expression
negative regulation of phosphatase activity
glial cell proliferation
L-glutamate transport
Wnt signaling pathway
positive regulation of macroautophagy
dephosphorylation
regulation of protein ubiquitination
negative regulation of TOR signaling
negative regulation of dephosphorylation
peptidyl-tyrosine dephosphorylation
regulation of protein import into nucleus
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cell cycle
carbohydrate phosphorylation
habituation
regulation of proteasomal protein catabolic process
regulation of protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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