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Proteintech
EPO Polyclonal Antibody
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Product Details
17908-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EPO Fusion Protein Ag12302 (3-193 aa encoded by BC093628)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Amount
21 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VHECPAWLW LLLSLLSLPL GLPVLGAPPR LICDSRVLER YLLEAKEAEN ITTGCAEHCS LNENITVPDT KVNFYAWKRM EVGQQAVEVW QGLALLSEAV LRGQALLVNS SQPWEPLQLH VDKAVSGLRS LTTLLRALGA QKEAISPPDA ASAAPLRTIT ADTFRKLFRV YSNFLRGKLK LYTGEACRTG DR (3-193 aa encoded by BC093628)
Target Information
Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epoetin; Erythropoietin; MGC138142; unnamed protein product
Gene Aliases: DBAL; ECYT5; EP; EPO; MVCD2
UniProt ID: (Human) P01588
Entrez Gene ID: (Human) 2056
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
regulation of transcription from RNA polymerase II promoter
apoptotic process
response to stress
acute-phase response
signal transduction
embryo implantation
response to nutrient
blood circulation
positive regulation of cell proliferation
response to salt stress
negative regulation of calcium ion transport into cytosol
positive regulation of neuron projection development
erythrocyte differentiation
response to lipopolysaccharide
myeloid cell apoptotic process
negative regulation of myeloid cell apoptotic process
response to vitamin A
response to testosterone
erythropoietin-mediated signaling pathway
positive regulation of activated T cell proliferation
hemoglobin biosynthetic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
erythrocyte maturation
response to estrogen
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of Ras protein signal transduction
response to axon injury
response to electrical stimulus
response to hyperoxia
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
cellular hyperosmotic response
response to dexamethasone
receptor signaling pathway via STAT
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
negative regulation of erythrocyte apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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