This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Epidermal growth factor receptor kinase substrate 8
Gene Aliases: DFNB102; EPS8
UniProt ID: (Human) Q12929
Entrez Gene ID: (Human) 2059
Molecular Function: transmembrane receptor regulatory/adaptor protein