Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGRKAIVLAI ANTSLAFPLC QHLVTFCLGE DDGVHTVEDA SRKLAVMDSQ GRVWAQEMLL RVSPDHVTLL DPASKEELES YPLGAIVRCD AVMPPGRSRS LLLLVCQEPE RAQPDVHFFQ GLRLGAELIR EDIQGALHNY RSGRGERRAA ALRATQEELQ RDRSPAAETP PLQRRPSVRA VISTVERGAG RGRPQAKPIP EAEEAQRPEP VGTSSNADSA SPDLGPRGPD LAVLQAEREV DILNHVFDDV ESFVSRLQKS AEAARVLEHR ERGRRSRRRA AGEGLLTLRA KPPSEAEYTD VLQKIKYAFS LLARLRGNIA DPSSPELLHF LFGPLQMIVN TSGGPEFASS VRRPHLTSDA VALLRDNVTP RENELWTSLG DSWTRPGLEL SPEEGPPYRP EFFSGWEPPV TDPQSRAWED PVEKQLQHER RRRQVTQATQ QGRGWEVRGR GRSAWPRLTR LSYFLQQSAP QVAVNGHRDL EPESEPQLES ETAGKWVLCN YDFQARNSSE LSVKQRDVLE VLEDKEKVSE LEAVMEKQKK KVEGEVEMEV I
Eps8L1 (EPS8-like 1), also known as DRC3 or EPS8R1, is a 723 amino acid protein that localizes to the cytoplasm and belongs to the Eps8 (epidermal growth factor receptor pathway substrate 8) family. Expressed in placental tissue, Eps8L1 functions to stimulate the guanine exchange activity of Sos 1 (son of sevenless homolog 1), a protein that promotes the exchange of Ras-bound GDP for GTP. Additionally, Eps8L1 is thought to associate with Actin and, via this association, may play a role in membrane ruffling and remodeling of the Actin cytoskeleton. Through its ability to regulate protein activation and cytoskeleton dynamics, Eps8L1 may participate in cell growth and differentiation events within the cell. Eps8L1 contains one SH3 domain and is expressed as four isoforms due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Epidermal growth factor receptor kinase substrate 8-like protein 1; Epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8-like 1; EPS8-like protein 1; EPS8-related protein 1
Gene Aliases: DRC3; EPS8L1; EPS8R1; PP10566
UniProt ID: (Human) Q8TE68
Entrez Gene ID: (Human) 54869
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