Immunogen sequence: MSLWESLGE SWMRPRSEWP REPQVPLYVP KFHSGWEPPV DVLQEAPWEV EGLASAPIEE VSPVSRQSIR NSQKHSPTSE PTPPGDALPP VSSPHTHRGC QPTPAMAKYV KILYDFTARN ANELSVLKDE VLEVLEDGRQ WWKLRSRSGQ AGYVPCNILG EARPEDAGAP FEQAGQKYWG PASPTHKLPP SFPGNKDELM QHMDEVNDEL IRKISNIRAQ PQRHFRVERS QPVSQPLTYE SGPDEVRAWL EAKAFSPRIV ENLGILTGPQ LFSLNKEELK KVCGEEGVRV YSQLTMQKAF LEKQQSGSEL EELMNKFHSM NQRRGEDS (389-715 aa encoded by BC002474)
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Epidermal growth factor receptor kinase substrate 8-like protein 2; epidermal growth factor receptor pathway substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8 related protein 2; EPS8-like 2; EPS8-like protein 2; EPS8-related protein 2
Gene Aliases: AI042819; AW545405; EPS8L2; EPS8R2; PP13181
Molecular Function: scaffold/adaptor protein