The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CEGA; Conserved ERA-like GTPase; era (E. coli G-protein homolog)-like 1; Era G-protein-like 1; Era-like 12S mitochondrial rRNA chaperone 1; ERA-like protein 1; ERA-W; GTP-binding protein era homolog; GTPase Era, mitochondrial; GTPase, human homolog of E. coli essential cell cycle protein Era; H-ERA
Gene Aliases: CEGA; ERA; ERA-W; ERAL1; ERAL1A; H-ERA; HERA; HERA-A; HERA-B
UniProt ID: (Human) O75616
Entrez Gene ID: (Human) 26284
Molecular Function: RNA metabolism protein