Anti-Human ERCC1 is an IgG2a Mouse Monoclonal Antibody that recognizes Excision Cross Complementing 1 (ERCC1), a human endonuclease. ERCC1 protein forms a complex with Xeroderma Pigmentosum Group F (XPF) protein. During nucleotide excision repair of damaged DNA, the ERCC1-XPF complex forms an incision at the 5' end of the DNA lesion. Deficiencies in the nucleotide excision repair pathway result in disorders such as Xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA excision repair protein ERCC-1; excision repair cross-complementation group 1; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency, complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
Gene Aliases: COFS4; Ercc-1; ERCC1; RAD10; UV20