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ERCC1 Polyclonal Antibody

View all (90) ERCC1 antibodies

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ERCC1 Polyclonal Antibody

Product Details

BS-1726R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human ERCC1, amino acids 151-250.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. (Uniprot)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: clone 2B3; DNA excision repair protein ERCC-1; excision repair cross-complementation group 1; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency, complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); unnamed protein product

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Gene Aliases: COFS4; Ercc-1; ERCC1; RAD10; UV20

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UniProt ID: (Human) P07992, (Mouse) P07903

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Entrez Gene ID: (Human) 2067, (Rat) 292673, (Mouse) 13870

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Function(s)
single-stranded DNA endodeoxyribonuclease activity TFIID-class transcription factor binding DNA binding damaged DNA binding single-stranded DNA binding protein binding 3' overhang single-stranded DNA endodeoxyribonuclease activity promoter-specific chromatin binding molecular_function protein C-terminus binding TBP-class protein binding protein domain specific binding structure-specific DNA binding nuclease activity endonuclease activity hydrolase activity endodeoxyribonuclease
Process(es)
pyrimidine dimer repair by nucleotide-excision repair telomere maintenance DNA repair nucleotide-excision repair double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination mitotic recombination syncytium formation cellular response to DNA damage stimulus response to oxidative stress germ cell development spermatogenesis cell proliferation determination of adult lifespan male gonad development UV protection response to X-ray regulation of telomere maintenance negative regulation of telomere maintenance post-embryonic hemopoiesis multicellular organism growth interstrand cross-link repair isotype switching insulin-like growth factor receptor signaling pathway cell development oogenesis chromosome organization positive regulation of transcription initiation from RNA polymerase II promoter telomeric DNA-containing double minutes formation UV-damage excision repair replicative senescence t-circle formation positive regulation of t-circle formation negative regulation of protection from non-homologous end joining at telomere DNA catabolic process, endonucleolytic replicative cell aging nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion response to nutrient response to sucrose multicellular organism aging embryonic organ development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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