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ERG/KCNH2 Polyclonal Antibody

View all (14) KCNH2 antibodies

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ERG/KCNH2 Polyclonal Antibody

Product Details

BS-23703R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human ERG/KCNH2, amino acids 751-850.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Eag homolog; eag-related protein 1; ERG-1; Ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related potassium channel protein; ether-a-go-go-related protein 1; HERG-1; human ether-a-go-go-related; long QT syndrome type 2; M-erg1; potassium channel, voltage gated eag related subfamily H, member 2; Potassium voltage-gated channel subfamily H member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; r-ERG; RERG; subfamily H; eag-related; Voltage-gated inwardly rectifying potassium channel KCNH2; Voltage-gated potassium channel subunit Kv11.1

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Gene Aliases: AI326795; ERG; ERG-1; ERG1; H-ERG; HERG; HERG1; KCNH2; Kv11.1; LQT; LQT2; M-erg; Merg1; merg1a; merg1b; SQT1

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UniProt ID: (Human) Q12809, (Mouse) O35219, (Rat) O08962

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Entrez Gene ID: (Human) 3757, (Mouse) 16511, (Rat) 117018

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Function(s)
transcription regulatory region sequence-specific DNA binding ion channel activity inward rectifier potassium channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity protein binding ubiquitin protein ligase binding identical protein binding protein homodimerization activity scaffold protein binding voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization phosphorelay sensor kinase activity signal transducer activity voltage-gated ion channel activity C3HC4-type RING finger domain binding voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization ion channel
Process(es)
regulation of heart rate by hormone ion transport potassium ion transport ion transmembrane transport regulation of membrane potential positive regulation of transcription, DNA-templated potassium ion homeostasis transmembrane transport cardiac muscle contraction regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization cellular response to xenobiotic stimulus potassium ion transmembrane transport ventricular cardiac muscle cell action potential membrane repolarization membrane depolarization during action potential membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction potassium ion export across plasma membrane cation transmembrane transport membrane repolarization during ventricular cardiac muscle cell action potential regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transport positive regulation of potassium ion transmembrane transport negative regulation of potassium ion export across plasma membrane potassium ion import across plasma membrane phosphorelay signal transduction system transport signal transduction regulation of ion transmembrane transport cellular response to drug protein heterooligomerization potassium ion export negative regulation of potassium ion export brain development spinal cord development signal transduction by protein phosphorylation
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