Immunogen sequence: KADAEYYAAH KYATSNKHKL TPEYLELKKY QAIASNSKIY FGSNIPNMFV DSSCALKYSD IRTGRESSLP SKEALEPSGE NVIQNKESTG; Positive Samples: 293T, HepG2, BxPC3, DU145, OVCAR-3, Mouse kidney, Rat testis; Cellular Location: Endoplasmic reticulum membrane, Single-pass type II membrane protein
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9; Endoplasmic reticulum lipid raft-associated protein 1; Erlin-1; OTTHUMP00000059425; OTTHUMP00000197867; Protein KE04; Protein KE04 homolog; SPFH domain family, member 1; SPFH domain-containing protein 1; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1
Gene Aliases: 2810439N09Rik; C10orf69; C80197; Erlin-1; ERLIN1; KE04; KEO4; RGD1307058; SPFH1; SPG62