Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-116228
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 883-911 amino acids from the C-terminal region of mouse Ern2
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2900862
Target Information
ERN2 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 2 protein is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Endoplasmic reticulum-to-nucleus signaling 2; ern2; inositol-requiring 1 (Yeast homologue); inositol-requiring 1 beta; Inositol-requiring protein 2; Ire1-beta; IRE1b; mIre1; Serine/threonine-protein kinase/endoribonuclease IRE2
Gene Aliases: Ern1; Ern2; Ire1; Ire1b; Ire2
UniProt ID: (Mouse) Q9Z2E3
Entrez Gene ID: (Mouse) 26918
nucleotide binding
magnesium ion binding
catalytic activity
endonuclease activity
ribonuclease activity
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
bidentate ribonuclease III activity
transferase activity
transferase activity, transferring phosphorus-containing groups
hydrolase activity
metal ion binding
endoribonuclease
transcription, DNA-templated
regulation of transcription, DNA-templated
mRNA processing
protein phosphorylation
apoptotic process
response to unfolded protein
cell cycle arrest
activation of JUN kinase activity
metabolic process
rRNA catabolic process
phosphorylation
apoptotic chromosome condensation
response to endoplasmic reticulum stress
negative regulation of transcription, DNA-templated
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
nucleic acid phosphodiester bond hydrolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support