FIGURE: 1 / 1
Immunogen sequence: EFHMQHPSTC PARDLTVATM AQGLGLETDA TEDDFGVWEV KTMVAVILHL LKEPSSQLFS KPEVIKQKYE TGPCSKADVV DSETVV
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 87%.
RBM35A, also known as ESRP2, is a mRNA splicing factor that with its related protein RBM35A (ESRP1) are coordinators of an epithelial cell-type-specific splicing program. Both RBM35B and RBM35A are involved in posttranscriptional regulation of a number of genes such as FGFR2, CD44, CTNND1, and ENAH by exerting a differential effect on protein translation via 5' UTRs of mRNAs, suggesting that these proteins are global regulators of an epithelial regulatory network. Loss of this global ESRP-regulated epithelial splicing program induces the phenotypic changes in cell morphology that are observed during the epithelial-mesenchymal transition.
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Protein Aliases: Epithelial splicing regulatory protein 2; RNA binding motif protein 35A; RNA binding motif protein 35B; RNA-binding motif protein 35B; RNA-binding protein 35B
Gene Aliases: ESRP2; PP7059; RBM35B
UniProt ID: (Human) Q9H6T0
Entrez Gene ID: (Human) 80004
Molecular Function: RNA splicing factor