Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Hamster, Panda, Horse (100%) Mouse, Rat, Elephant, Bovine, Bat, Rabbit, Pig (93%) Dog (86%).
ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).
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Protein Aliases: DFNB35; ERR beta-2; ERR-beta; ERR2; ERRb; ERRB2; ERRbeta; ERRbeta-2; ESRL2; ESRRB; Estrogen receptor-like 2; estrogen-related nuclear receptor beta; Estrogen-related receptor 2; Estrogen-related receptor beta; NR3B2; Nuclear receptor ERRB2; Nuclear receptor subfamily 3 group B member 2; Orphan nuclear receptor; Steroid hormone receptor ERR2
Gene Aliases: DFNB35; ERR2; ERRb; ERRB2; ESRL2; ESRRB; NR3B2
UniProt ID: (Human) O95718
Entrez Gene ID: (Human) 2103