Estrogen related receptor (ERR gamma), a NR3 Steroid Receptor, has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half-site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC-1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre-mRNA undergoes extensive alternative splicing at the 5 prime end, yeilding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development.
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Protein Aliases: ERR Gamma; ERR gamma-2; Err-gamma; ERR3; ERRG2; ERRgamma; ESRRG; Estrogen receptor-related protein 3; Estrogen-related receptor gamma; KIAA0832; NR3B3; Nuclear receptor subfamily 3 group B member 3
Gene Aliases: ERR3; ERRG2; ERRgamma; ESRRG; KIAA0832; NR3B3
UniProt ID: (Human) P62508
Entrez Gene ID: (Human) 2104