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7TM Antibodies
ETA, Endothelin Receptor A Polyclonal Antibody
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FIGURE: 1 / 5
ETA, Endothelin Receptor A Antibody (7TM0219N-IC) in IHC (P)
Immunohistochemical identification of Endothelin Receptor A in mouse heart. Sections were dewaxed, microwaved in citric acid, and incubated with anti-ETA (Endothelin receptor A) antibody (7TM0219N-IC) at a dilution of 1:100. Sections were then sequentially treated with biotinylated anti-rabbit IgG and avidin-biotin solution. Color was developed by incubation in 3-amino-9-ethylcarbazole (AEC) , and sections ... View More
Product Details
7TM0219N-IC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide with sequence KNHDQNNHNTDRSSHKDSMN corresponds to amino acids 408 - 427 in human, mouse and rat ETA.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Endothelin A; endothelin A receptor; endothelin receptor subtype A; Endothelin receptor type A; Endothelin-1 receptor; endothelin-1-specific receptor; ET-A; G protein-coupled receptor; G-protein coupled receptor 10
Gene Aliases: EDNRA; Endor; ET-A; ET-AR; ETA; ETA-R; ETAR; ETRA; Gpcr10; hET-AR; MFDA; RGD1559432
UniProt ID: (Human) P25101, (Rat) P26684, (Mouse) Q61614
Entrez Gene ID: (Human) 1909, (Rat) 24326, (Mouse) 13617
patterning of blood vessels
response to hypoxia
in utero embryonic development
histamine secretion
glomerular filtration
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
Rho protein signal transduction
heart development
aging
respiratory gaseous exchange
regulation of blood pressure
cell proliferation
positive regulation of cell proliferation
neural crest cell development
artery smooth muscle contraction
glucose transport
sensory perception of pain
negative regulation of cAMP biosynthetic process
response to lipopolysaccharide
vasoconstriction
positive regulation of odontogenesis
negative regulation of apoptotic process
penile erection
response to morphine
fibroblast proliferation
enteric nervous system development
smooth muscle cell proliferation
regulation of epithelial cell proliferation
positive regulation of inflammatory response
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
maternal process involved in parturition
head development
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
endothelin receptor signaling pathway
positive regulation of neutrophil chemotaxis
positive regulation of kidney development
positive regulation of protein phosphorylation
response to organic cyclic compound
positive regulation of calcium ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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