Recommended positive controls: 293T, A431, HeLa, HepG2, C8D30, PC-12.
Predicted reactivity: Mouse (96%), Rat (95%), Zebrafish (84%), Xenopus laevis (85%), Cat (96%), Pig (96%), Chicken (87%), Rhesus Monkey (98%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-ETF; electron transfer flavoprotein alpha-subunit; Electron transfer flavoprotein subunit alpha, mitochondrial; electron transfer flavoprotein, alpha polypeptide; electron transferring flavoprotein, alpha polypeptide; electron-transfer-flavoprotein alpha polypeptide; glutaric aciduria II
Gene Aliases: 2010200I21Rik; D9Ertd394e; EMA; ETF; ETFA; GA2; MADD
Molecular Function: oxidoreductase