Invitrogen

ETS1 Polyclonal Antibody

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ETS1 Polyclonal Antibody

Product Details

PA5-86080

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to the N-terminus of Human ETS1.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2802880

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54), a 441 A. A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependent IL-5 expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; avian erythroblastosis virus E26 oncogene 1; Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1); ets protein; Ets-1Delta(III-VI); FLJ10768; p54; Protein C-ets-1; tumor progression locus 1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1

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Gene Aliases: AI196000; AI448617; c-ets-1; D230050P06; ETS-1; ETS1; Etsoncb; EWSR2; p54; Tpl1

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UniProt ID: (Human) P14921, (Rat) P41156, (Mouse) P27577

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Entrez Gene ID: (Human) 2113, (Rat) 24356, (Mouse) 23871

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding histone acetyltransferase binding identical protein binding sequence-specific DNA binding winged helix/forkhead transcription factor
Process(es)
response to hypoxia immune response female pregnancy positive regulation of cell proliferation negative regulation of cell proliferation response to mechanical stimulus positive regulation of endothelial cell migration regulation of extracellular matrix disassembly hypothalamus development pituitary gland development PML body organization response to estradiol response to laminar fluid shear stress estrous cycle positive regulation of erythrocyte differentiation regulation of angiogenesis positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell motility negative regulation of inflammatory response positive regulation of inflammatory response positive regulation of cellular component movement angiogenesis involved in wound healing pri-miRNA transcription from RNA polymerase II promoter cellular response to hydrogen peroxide response to interleukin-1 positive regulation of leukocyte adhesion to vascular endothelial cell immune system process regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter response to wounding cell differentiation positive regulation of cell migration regulation of apoptotic process negative regulation of cell cycle response to antibiotic transcription, DNA-templated regulation of transcription, DNA-templated
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