Immunogen sequence: AFHGLPLKIK KEPHSPCSEI SSACSQEQPF KFSYGEKCLY NVSAYDQKPQ VGMRPSNPPT PSSTPVSPLH HASPNSTHTP KPDRAFPAHL PPSQSIPDSS YPMDHRFRRQ LSEPCNSFPP LPTMPREGRP MYQRQMSEPN IPFPPQGFKQ EYHDPVYEHN TMVGSAASQS FPPPLMIKQE PRDFAYDSEV PSCHSIYMRQ EGFLAHPSRT EGCMFEKGPR Q; Cellular Location: Nucleus
ETV1: ets variant gene 1. Several members of the Ets gene family encode sequence-specific DNA binding proteins that recognize DNA sequences with a centrally located 5'-GGAA-3' element. All of the Ets proteins recognize the same central core sequence but each protein interacts with unique sequences that flank this core. ER81 (also designated ETV1) binds the motif 5'-CGGAA/T-3'. ER81 is highly expressed in brain, testis, lung and heart. ER81 is also moderately expressed in spleen, pancreas, colon and small intestine. During development, ER81 displays a unique expression patterns which suggests that this transcriptional factor might play an important role in organogenesis. ERK-1 activates ER81 transcriptional activity while MAPKAP kinase 2 inhibits ER81.
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Protein Aliases: ets related protein 81; ETS translocation variant 1; ets variant gene 1; Ets-related protein 81
Gene Aliases: ER81; Etsrp81; ETV1