Invitrogen

EXO1 Polyclonal Antibody

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EXO1 Antibody in Immunofluorescence (IF) — Immunofluorescent analysis of A549 cells using an EXO1 polyclonal antibody (Product # PA5-12501) at a dilution of 1:10-50, followed by a fluor-conjugated goat anti-rabbit secondary antibody (green). Nuclei were stained with DAPI (blue).

EXO1 Antibody in Western Blot (WB) — Western blot analysis using an EXO1 polyclonal antibody (Product # PA5-12501) in NCI-H460 cell lysates (35 µg per lane).

Product Details

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC)

1:10-1:50

Immunofluorescence (IF)

1:10-1:50

Western Blot (WB)

1:1000

Product Specifications

Species

Human

Expression System

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EXO1

Conjugate

Unconjugated

Form

Liquid

Concentration

Lot-specific

Purification

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2101425

Target Information

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Exonuclease 1; Exonuclease I; hExo1; hExoI; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1

Gene Aliases: EXO1; EXOI; HEX1; hExoI

UniProt ID: (Human) Q9UQ84

Entrez Gene ID: (Human) 9156

Molecular Function: DNA binding protein damaged DNA-binding protein endodeoxyribonuclease exodeoxyribonuclease hydrolase nuclease nucleic acid binding

Function(s)

DNA synthesis involved in DNA repair strand displacement humoral immune response mediated by circulating immunoglobulin DNA replication DNA repair mismatch repair DNA recombination somatic hypermutation of immunoglobulin genes isotype switching meiotic cell cycle RNA phosphodiester bond hydrolysis, endonucleolytic regulation of signal transduction by p53 class mediator

Process(es)

DNA binding chromatin binding RNA-DNA hybrid ribonuclease activity exonuclease activity protein binding 5'-3' exonuclease activity 5'-3' exodeoxyribonuclease activity single-stranded DNA 5'-3' exodeoxyribonuclease activity metal ion binding flap endonuclease activity double-stranded DNA 5'-3' exodeoxyribonuclease activity

EXO1 Polyclonal Antibody

Product Details

Target Information

References (0)

Bioinformatics

Material safety data sheets (MSDS)

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