Invitrogen

EXO1 Polyclonal Antibody

View all (14) EXO1 antibodies

Questions & Answers

Questions & Answers

Product Image Gallery

EXO1 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of A549 cells using an EXO1 polyclonal antibody (Product # PA5-12501) at a dilution of 1:10-50, followed by a fluor-conjugated goat anti-rabbit secondary antibody (green). Nuclei were stained with DAPI (blue).

EXO1 Antibody in Western Blot (WB) — Western blot analysis using an EXO1 polyclonal antibody (Product # PA5-12501) in NCI-H460 cell lysates (35 µg per lane).

Product Details

PA5-12501

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000	-
Immunocytochemistry (ICC/IF)	1:10-1:50	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EXO1 View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	2 mg/mL
Purification	Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer	PBS
Contains	0.09% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2101425

Target Information

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?

Let us know so we can reference it here.

Cite this product

Bioinformatics

Protein Aliases: Exonuclease 1; Exonuclease I; hExo1; hExoI; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1

Gene Aliases: EXO1; EXOI; HEX1; hExoI

UniProt ID: (Human) Q9UQ84

Entrez Gene ID: (Human) 9156

Molecular Function: exodeoxyribonuclease

DNA synthesis involved in DNA repair strand displacement humoral immune response mediated by circulating immunoglobulin DNA replication DNA repair mismatch repair DNA recombination somatic hypermutation of immunoglobulin genes isotype switching meiotic cell cycle RNA phosphodiester bond hydrolysis, endonucleolytic regulation of signal transduction by p53 class mediator

Process(es)

DNA binding chromatin binding RNA-DNA hybrid ribonuclease activity exonuclease activity protein binding 5'-3' exonuclease activity 5'-3' exodeoxyribonuclease activity single-stranded DNA 5'-3' exodeoxyribonuclease activity metal ion binding flap endonuclease activity double-stranded DNA 5'-3' exodeoxyribonuclease activity