Invitrogen

EXO1 Polyclonal Antibody

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EXO1 Antibody in Western Blot (WB) — Western blot analysis of EXO1 in Lane 1: rat testis tissue lysate (40 µg), Lane 2: Testis tissue lysate of mouse (40 µg), Lane 3: K562 whole cell lysate (10 µg), Lane 4: HEK293T whole cell lysate (10 µg). Sample was incubated with EXO1 polyclonal antibody (Product # PA5-86470) using a 1:500 dilution.

Product Details

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC)

1:50-1:200

Immunofluorescence (IF)

1:50-1:200

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Western Blot (WB)

1:500-1:1000

Product Specifications

Species

Human, Mouse, Rat

Expression System

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 55-05 of Human Exo1.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2803248

Target Information

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Exonuclease 1; Exonuclease I; hExo1; hExoI; mExo1; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1

Gene Aliases: 5730442G03Rik; EXO1; EXOI; HEX1; hExoI; Msa

UniProt ID: (Human) Q9UQ84, (Mouse) Q9QZ11

Entrez Gene ID: (Human) 9156, (Rat) 305000, (Mouse) 26909

Molecular Function: DNA binding protein damaged DNA-binding protein endodeoxyribonuclease exodeoxyribonuclease hydrolase nuclease nucleic acid binding

Function(s)

DNA synthesis involved in DNA repair strand displacement humoral immune response mediated by circulating immunoglobulin DNA replication DNA repair mismatch repair DNA recombination somatic hypermutation of immunoglobulin genes isotype switching meiotic cell cycle RNA phosphodiester bond hydrolysis, endonucleolytic regulation of signal transduction by p53 class mediator DNA catabolic process, endonucleolytic DNA catabolic process, exonucleolytic biological_process immune system process nucleobase-containing compound metabolic process cellular response to DNA damage stimulus nucleic acid phosphodiester bond hydrolysis

Process(es)

DNA binding chromatin binding RNA-DNA hybrid ribonuclease activity exonuclease activity protein binding 5'-3' exonuclease activity 5'-3' exodeoxyribonuclease activity single-stranded DNA 5'-3' exodeoxyribonuclease activity metal ion binding flap endonuclease activity double-stranded DNA 5'-3' exodeoxyribonuclease activity molecular_function structure-specific DNA binding catalytic activity nuclease activity endonuclease activity hydrolase activity hydrolase activity, acting on ester bonds phosphoric ester hydrolase activity T/G mismatch-specific endonuclease activity retroviral 3' processing activity

EXO1 Polyclonal Antibody

Product Details

Target Information

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Bioinformatics

Material safety data sheets (MSDS)

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