Proteintech

EXOSC1 Polyclonal Antibody

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EXOSC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lymphoma using 12585-1-AP (EXOSC1 antibody) at dilution of 1:100 (under 10x lens).

EXOSC1 Antibody in Western Blot (WB) — Human stomach tissue were subjected to SDS PAGE followed by western blot with 12585-1-AP (EXOSC1 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours.

EXOSC1 Antibody in Immunoprecipitation (IP) — IP result of anti-EXOSC1 (IP:12585-1-AP, 4ug; Detection:12585-1-AP 1:600) with HeLa cells lysate 3000 ug.

Product Details

12585-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	EXOSC1 Fusion Protein Ag3286 (1-195 aa encoded by BC022067) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.23 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MAPPVRYCI PGERLCNLEE GSPGSGTYTR HGYIFSSLAG CLMKSSENGA LPVVSVVRET ESQLLPDVGA IVTCKVSSIN SRFAKVHILY VGSMPLKNSF RGTIRKEDVR ATEKDKVEIY KSFRPGDIVL AKVISLGDAQ SNYLLTTAEN ELGVVVAHSE SGIQMVPISW CEMQCPKTHT KEFRKVARVQ PEFLQT (1-195 aa encoded by B C022067)

Target Information

This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3'-5' exoribonuclease CSL4 homolog; exosomal core protein CSL4; Exosome complex component CSL4; Exosome component 1; hCsl4p; homolog of yeast exosomal core protein CSL4; RP11-452K12.9

Gene Aliases: 2610035C18Rik; 2610104C07Rik; 2610312F07Rik; AI447561; CGI-108; CSL4; Csl4p; EXOSC1; p13; SKI4; Ski4p

UniProt ID: (Human) B2R9B3, (Mouse) Q9DAA6

Entrez Gene ID: (Human) 51013, (Rat) 679140, (Mouse) 66583

Molecular Function: RNA metabolism protein exoribonuclease nucleic acid metabolism protein