FIGURE: 1 / 3
Immunogen sequence: APPVRYCIPG ERLCNLEEGS PGSGTYTRHG YIFSSLAGCL MKSSENGALP VVSVVRETES QLLPDVGAIV TCKVSSINSR FAKVHILYVG SMPLKNS
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3'-5' exoribonuclease CSL4 homolog; exosomal core protein CSL4; Exosome complex component CSL4; Exosome component 1; hCsl4p; homolog of yeast exosomal core protein CSL4; RP11-452K12.9
Gene Aliases: 2610035C18Rik; 2610104C07Rik; 2610312F07Rik; AI447561; CGI-108; CSL4; Csl4p; EXOSC1; p13; SKI4; Ski4p