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Proteintech
EXOSC10 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
16731-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EXOSC10 Fusion Protein Ag10189 (540-885 aa encoded by BC073788)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.24 mg/mL
Amount
36 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IAEELPKEP QGIIACCNPV PPLVRQQINE MHLLIQQARE MPLLKSEVAA GVKKSGPLPS AERLENVLFG PHDCSHAPPD GYPIIPTSGS VPVQKQASLF PDEKEDNLLG TTCLIATAVI TLFNEPSAED SKKGPLTVAQ KKAQNIMESF ENPFRMFLPS LGHRAPVSQA AKFDPSTKIY EISNRWKLAQ VQVQKDSKEA VKKKAAEQTA AREQAKEACK AAAEQAISVR QQVVLENAAK KRERATSDPR TTEQKQEKKR LKISKKPKDP EPPEKEFTPY DYSQSDFKAF AGNSKSKVSS QFDPNKQTPS GKKCIAAKKI KQSVGNKSMS FPTGKSDRGF RYNWPQR (540-885 aa encoded by BC073788 )
Target Information
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: autoantigen PM-SCL; autoantigen PM/Scl 2 homolog; P100 polymyositis-scleroderma overlap syndrome associated autoantigen homolog; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl; polymyositis/scleroderma autoantigen 100 kDa; polymyositis/scleroderma autoantigen 2; polymyositis/scleroderma autoantigen 2 homolog; unnamed protein product
Gene Aliases: p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p
UniProt ID: (Human) Q01780, (Mouse) P56960
Entrez Gene ID: (Human) 5394, (Mouse) 50912
maturation of 5.8S rRNA
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
nuclear-transcribed mRNA catabolic process
RNA processing
RNA catabolic process
regulation of gene expression
negative regulation of telomere maintenance via telomerase
ribosomal small subunit biogenesis
nuclear mRNA surveillance
CUT catabolic process
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent snoRNA catabolic process
nuclear polyadenylation-dependent snRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
nuclear polyadenylation-dependent CUT catabolic process
nuclear polyadenylation-dependent antisense transcript catabolic process
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
regulation of telomerase RNA localization to Cajal body
positive regulation of mRNA cis splicing, via spliceosome
rRNA processing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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