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Invitrogen
EXOSC10 Polyclonal Antibody
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Product Details
PA5-55869
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PM-Scl. Recombinant protein control fragment (Product #RP-94454).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KVTELEDKFD LLVDANDVIL ERVGILLDEA SGVNKNQQPV LPAGLQVPKT VVSSWNRKAA EYGKKAKSET FRLLHA
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: autoantigen PM-SCL; Autoantigen PM/Scl 2; Exosome complex component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-100; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2
Gene Aliases: EXOSC10; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p
UniProt ID: (Human) Q01780
Entrez Gene ID: (Human) 5394
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
dosage compensation by inactivation of X chromosome
nuclear mRNA surveillance
CUT catabolic process
nuclear polyadenylation-dependent rRNA catabolic process
histone mRNA catabolic process
nuclear retention of unspliced pre-mRNA at the site of transcription
RNA phosphodiester bond hydrolysis, exonucleolytic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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