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This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Autoantigen PM/Scl 1; EXOSC9; Exosome complex component RRP45; exosome complex exonuclease RRP45; Exosome component 9; p5; p6; P75 polymyositis-scleroderma overlap syndrome associated autoantigen; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl 75; PM/Scl-75; PMSCL autoantigen, 75kD; PMSCL1; Polymyositis/scleroderma autoantigen 1; polymyositis/scleroderma autoantigen 1, 75kDa; Polymyositis/scleroderma autoantigen 75 kDa; RRP45; Rrp45p
Gene Aliases: EXOSC9; p5; p6; PM/Scl-75; PMSCL1; RRP45; Rrp45p
UniProt ID: (Human) Q06265
Entrez Gene ID: (Human) 5393
Molecular Function:
RNA binding protein
exoribonuclease
hydrolase
nuclease
nucleic acid binding
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