Immunogen sequence: ALPPRPRPGA SQGWPRWLDA ELLQSFSQPG ELPEDAVSPP QAPHGGSCNW ESCFDTSKCR GDGLKVFVYP AVGTISETHR RILASIEGS
Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 61%.
This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin.
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Protein Aliases: alpha-N-acetylglucosaminyltransferase II; EC 220.127.116.11; exostoses (multiple)-like 1; Exostosin-L; Exostosin-like 1; exostosin-like glycosyltransferase 1; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Glucuronosyl-N-acetylglucosaminyl-proteoglycan4-alpha-N-acetylglucosaminyltransferase; glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase; MGC70794; Multiple exostosis-like protein
Gene Aliases: EXTL; EXTL1
UniProt ID: (Human) Q92935
Entrez Gene ID: (Human) 2134
Molecular Function: glycosyltransferase