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EYA2 Polyclonal Antibody
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Product Details
BS-13125R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human EYA2, amino acids 201-300.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Drosophila-type eyes absent 2-like protein; eyes absent 2 homolog; Eyes absent homolog 2; probable transcription factor; Protein phosphatase EYA2; putative transcription factor; similar to Drosophila eyes absent gene; unnamed protein product
Gene Aliases: EAB1; EYA2
UniProt ID: (Human) O00167, (Mouse) O08575
Entrez Gene ID: (Human) 2139, (Rat) 156826, (Mouse) 14049
protein dephosphorylation
multicellular organism development
striated muscle tissue development
histone dephosphorylation
peptidyl-tyrosine dephosphorylation
extrinsic apoptotic signaling pathway in absence of ligand
mitochondrial outer membrane permeabilization
DNA repair
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
chromatin modification
chromatin organization
chromatin remodeling
mesodermal cell fate specification
cell differentiation
positive regulation of DNA repair
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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