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EYA4 Polyclonal Antibody
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Product Details
BS-13126R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human EYA4, amino acids 301-400.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ78N10.1 (eyes absent); Eyes absent homolog 4; eyes absent homolog 4 (Drosophila) isoform EYA4_1; eyes absent homolog 4 (Drosophila) isoform EYA4_2; eyes absent-like protein 4; Protein phosphatase EYA4; unnamed protein product
Gene Aliases: B130023L16Rik; CMD1J; DFNA10; EYA4
UniProt ID: (Human) O95677, (Mouse) Q9Z191
Entrez Gene ID: (Human) 2070, (Rat) 292172, (Mouse) 14051
sensory perception of sound
peptidyl-tyrosine dephosphorylation
middle ear morphogenesis
inner ear development
DNA repair
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
multicellular organism development
chromatin modification
chromatin organization
visual perception
anatomical structure morphogenesis
cell differentiation
positive regulation of DNA repair
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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